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Review Open access Sep 2026

The DsbA-L paradox in protective and pathogenic stress adaptation

Summary Disulfide-bond A oxidoreductase-like protein (DsbA-L), also known as glutathione S-transferase kappa 1 (GSTK1), regulates adiponectin assembly, organelle homeostasis, and cellular responses to metabolic stress. Evidence from cellular knockdown, constitutive and tissue-specific knockout models, and studies of me...

Ying-Ying Deng, Long Yan, Xian-Ling Liu et al. · 0 citations
Open access Sep 2026

Gentiopicroside Attenuates Renal Ischemia-Reperfusion Injury through Suppression of JNK/MAPK Signaling.

BACKGROUND Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) with significant clinical impact. Gentiopicroside (GPS), a natural secoiridoid glycoside isolated from traditional medicinal plants, has been reported to exert anti-inflammatory and cytoprotective activities, yet its potent...

Lan Luo, Jia Liu, Na Zhang et al. · 0 citations

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