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Wen-Neng Wu

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Oct 2026

An ESIPT-based ratiometric fluorescent probe for cysteine and its application in complex matrices: milk and fetal bovine serum.

Cysteine (Cys) was an essential biothiol whose dysregulation is linked to neurotoxicity, liver injury, childhood growth retardation, and cardiovascular diseases, making its accurate detection critical for clinical diagnosis and biochemical research. Although excited-state intramolecular proton transfer (ESIPT)-based fl...

Qiang Fei, Yan-Bi Luo, Feng-Cai Zhou et al. · 0 citations
Open access Sep 2026

Novel Trifluoromethyl-Substituted Dipyrimidinamine Derivatives as Potential Antifungal Agents for Controlling Postharvest Soft Rot in Kiwifruit

Postharvest soft rot poses a severe threat to the kiwifruit industry. In response to this challenge, 20 trifluoromethyl-substituted dipyrimidinamine derivatives were designed and synthesized based on the molecular hybridization strategy. The bioassay results showed that most of the target compounds exhibited good inhib...

Wen-Neng Wu, Jing-Yan Zhao, Peng Geng et al. · 0 citations
Open access Jul 2026

Design and Synthesis of Novel Trifluoromethylpyrimidinamine Derivatives Bearing an Amide Moiety for Targeting Plant Pathogens

The potent antibacterial activity of compound 7i supports its potential application in the prevention and control of plant disease and molecular docking simulations of compound 7i with the FtsZ protein further confirmed its superior activity.

Wen-Neng Wu, Peng Geng, Qiang Fei et al. · 0 citations
Jul 2026

Synthesis, X-ray crystallography, DFT study of 5-chloro-2-((2-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)aniline, and its antifungal activity

The title compound exhibited promising antifungal efficacy, highlighting its potential as a new fungicide candidate and the calculated optimal structure was consistent with the crystal structure obtained from X-ray single-crystal diffraction.

Fengwei Ma, Yunfei Zhang, Zhenghong Jia et al. · 0 citations

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