Author

Wen-Qian Zhao

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Open access Oct 2026

ITGB2 promotes HIF-1α/GLUT1 mediated glucose metabolic reprogramming in renal tubular epithelial cells to aggravate the progression of diabetic kidney disease

Diabetic kidney disease (DKD) is characterized by tubular metabolic remodeling, inflammation, and profibrotic injury. However, whether integrin β2 (ITGB2) links high-glucose (HG) stress to hypoxia-inducible factor-1α (HIF-1α)/glucose transporter 1 (GLUT1)-dependent metabolic reprogramming in renal tubular epithelial ce...

Jun Peng, Qiao-Meng Yuan, Lu Zhou et al. · Cytotechnology (Dordrecht) · 0 citations

Open access Sep 2026

Mitochondrial dysfunction drives metabolic reprogramming in Gitelman syndrome: insights from proteomics and isogenic modeling

Gitelman syndrome (GS) is an autosomal recessive tubulopathy caused by SLC12A3gene mutations. While electrolyte disturbances are well-defined, the systemic metabolic consequences and underlying mechanisms remain unclear. This study investigated whether SLC12A3mutation drives mitochondrial dysfunction and consequent met...

Hong-Han Zhang, Wen-Qian Zhao, Lan-Xin Ma et al. · Human Genetics · 0 citations