The ubiquitin-editing enzyme A20 (TNFAIP3): mechanisms of activation, biological function, diseases and therapeutic targets
A20, encoded by tumor necrosis factor alpha-induced protein 3 (TNFAIP3), is a ubiquitin-editing enzyme that acts as a central regulator of inflammatory signal termination, immune homeostasis and tissue protection. By controlling receptor-proximal ubiquitin signaling, A20 limits the amplitude and duration of inflammator...