Author

Wen Tan

3 papers indexed here

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Open access Aug 2026

Mutant TP53 hijacks RNA-splicing factor RBM28 to suppress double-stranded RNA triggered antitumor immunity

TP53 mutation may not only compromise its multifaceted tumor-suppressive functions but also confer oncogenic properties. Here, we demonstrate that DNA-binding domain mutations of TP53 unexpectedly confer a transcriptional regulatory function, directly driving RNA-splicing factor RBM28 overexpression. Overexpressed RBM2...

Tao Xiang, Zi-Yi He, Xiao Hu et al. · Nature Communications · 0 citations

Open access Aug 2026

IFI44L modulates chemoradiotherapy sensitivity and CD8+ T cell infiltration in colorectal cancer

By promoting CCL5-mediated CD8+ T cell recruitment, IFI44L links tumor-intrinsic molecular alterations with antitumor immune responses and may represent a potential biomarker or therapeutic target for improving CRT efficacy.

Linlin Zheng, Meng-Jie Li, Ruoqing Yan et al. · Frontiers in Oncology · 0 citations

Open access Aug 2026

HDGF induces inflammatory cancer-associated fibroblast formation through ENO1-mediated glycolytic reprogramming in esophageal squamous-cell carcinoma.

An HDGF/ENO1/H4K12la/iCAF axis that links tumor metabolic reprogramming, stromal inflammatory activation, and immunosuppression in ESCC is revealed, identifying this axis as a promising therapeutic target for overcoming immunotherapy resistance.

Zhengqing Song, Cai-Nan Li, Pujie Wu et al. · Cancer Letters · 0 citations