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Author

Wen-Wei Li

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Aug 2026

Lead Optimization of Quinoline-Coumarin KRAS mRNA G-Quadruplex Ligands: Discovery of Non-Quaternary Ammonium Analogs as Translation Inhibitors.

This study designed and synthesized a series of nonquaternary ammonium analogs to investigate whether this structural motif could be removed without compromising KRAS rG4-related activity and identified Q29 as a promising lead for further development of KRAS translation inhibitors.

Mao-Lin Li, Wen-Wei Li, Wen-Li Fu et al. · 0 citations

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