Aug 2026
Lead Optimization of Quinoline-Coumarin KRAS mRNA G-Quadruplex Ligands: Discovery of Non-Quaternary Ammonium Analogs as Translation Inhibitors.
This study designed and synthesized a series of nonquaternary ammonium analogs to investigate whether this structural motif could be removed without compromising KRAS rG4-related activity and identified Q29 as a promising lead for further development of KRAS translation inhibitors.
Mao-Lin Li, Wen-Wei Li, Wen-Li Fu et al.
· Journal of Medicinal Chemist... · 0 citations