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Author

Wen-Xun Xiao

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Review Aug 2026

AKAP12 as a signal-compartmentalizing Hub across diseases: Context-dependent functions and translational potential.

A-kinase anchoring protein 12 (AKAP12; Gravin/SSeCKS) is a multidomain scaffold that coordinates spatially restricted signaling rather than acting as a single linear effector. By organizing protein kinase A (PKA), protein kinase C (PKC), phosphodiesterases (PDEs), proto-oncogenic non-receptor tyrosine kinase (Src)-rela...

Jiao Tian, Yuyuan Lu, Tao Wu et al. · 0 citations

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