Author

Wen-Yi Zhang

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Review Open access Jul 2026

Targeting Picornavirus Nonstructural 2C Protein: Structure, Function, and Antiviral Discovery

Current evidence supports 2C as a tractable yet still underexploited antiviral target for medically important picornaviruses.

Kan Li, Guang-Jin Fan, Wen-Yi Zhang et al. · ACS Infectious Diseases · 0 citations

Open access Aug 2026

Development of Covalent Inhibitors of Chikungunya Virus nsP2 Cysteine Protease Enabled by Direct-to-Biology Synthesis and Screening

A rapid drug development platform that integrates covalent docking with direct-to-biology (D2B) synthesis and screening to identify nsP2 inhibitors is presented, which establish a streamlined strategy for covalent inhibitor development and provide promising leads for CHIKV antiviral development.

Zheng-Jun Cai, Kan Li, Sainetra Sridhar et al. · Journal of Medicinal Chemist... · 1 citation