Open access
Aug 2026
Design and synthesis of 1,2,4-oxadiazole-functionalized funtumine derivatives as potent anticancer agents
Mechanical investigations indicated that 4m triggered apoptosis in a dose-dependent manner and modified the transcriptomic profile of HepG2 cells, affecting crucial pathways such as chemical carcinogenesis-DNA adducts, steroid hormone biosynthesis, and cytochrome P450-mediated xenobiotic metabolism.
Longyun Zhang, Yafang Chen, Ming-Jiang Lu et al.
· Arabian Journal of Chemistry · 0 citations