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Author

Wen-Yu Wu

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Open access Sep 2026

Deciphering the therapeutic mechanisms of Qingfei Litan prescription in acute lung injury: an integrated framework of UHPLC–MS/MS, systems pharmacology, machine learning, and in vivo validation

Background Acute lung injury (ALI) is primarily defined by hyper-inflammation and the breakdown of the alveolar-capillary barrier, frequently culminating in refractory respiratory failure. Current clinical interventions—predominantly glucocorticoids and supportive therapies—often yield suboptimal outcomes and are assoc...

Wen-Yu Wu, Shao-Feng Zhan, Kai Wang · 0 citations
Review Open access Sep 2026

Gut microbiota–immune–metabolic crosstalk in acute lung injury: integrating the gut–lung axis from mechanism to therapeutic targeting

The gut is increasingly recognized as a central immunological organ that orchestrates host immune responses and modulates distant mucosal sites, particularly the respiratory tract. In critical illness, disruption of intestinal barrier integrity and microbial homeostasis facilitates the translocation of bacteria, endoto...

Wen-Yu Wu, Zhen-Yang Wang, Yi-Yan Li et al. · 0 citations

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