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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Wen-Yuan Zhu

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2 papers indexed here

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Open access Sep 2026

Personalized proteomic analysis of human colorectal cancer identifies novel biomarkers associated with tumor progression

Colorectal cancer (CRC), one of the most common gastrointestinal malignancies, imposes a substantial clinical burden worldwide owing to its high morbidity and mortality. In this study, we collected twenty-five pairs of tumor and matched normal adjacent tissues from CRC patients at different Tumor‑Node‑Metastasis (TNM...

Qi Zhang, Wen-Yuan Zhu, Jian-Guo Ji et al. · 0 citations
Aug 2026

Nuclear-targeted GDOWN1 potently suppresses tumors by inducing premature transcription termination and exporting Pol Ⅱ CTD phosphatases to activate RB.

A novel interconnected regulatory cascade triggered by nuclear translocation of GDOWN1 is uncovered: it remodels Pol II phosphorylation landscape and induces global transcriptional repression, which further drives cytoplasmic kinase-phosphatase coordination to activate master cell cycle suppressors and ultimately arres...

Zhanwu Zhu, Jin-Jing Hu, Wen-Yuan Zhu et al. · 0 citations

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