Author

Wenzhi Deng

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Open access Sep 2026

METTL3-mediated m6A modification of RBM39 promotes cancer stemness and tumor progression in head and neck squamous cell carcinoma

RBM39 plays an important regulatory role in multiple cancers. However, its systematic function across pan-cancer and its specific mechanism in head and neck squamous cell carcinoma (HNSC) remain unclear. In this study, we performed pan-cancer expression and survival analyses based on TCGA and GTEx databa...

Yu Xin, Wen-Zhi Deng, Chu-Yang Jiang et al. · Discover Oncology · 0 citations

Review Open access Jul 2026

RNA epitranscriptomic regulation of tumor immune evasion: mechanisms, context-dependent roles, and therapeutic implications

Clinical translation remains limited by insufficient specificity, tumor heterogeneity, complex crosstalk among RNA modifications, potential toxicity, and delivery barriers, so future studies integrating RNA modification mapping with single-cell, spatial, and multi-omics technologies will be essential to define cell-typ...

Yan-Ni Ma, Wen-Zhi Deng, Xiu-Lin Jiang et al. · Frontiers in Immunology · 0 citations

Review Open access Jul 2026

Primary and acquired resistance to immunotherapy in NSCLC

This review summarizes immune resistance in NSCLC through a framework that distinguishes primary resistance from acquired resistance, and discusses mechanism-based biomarkers, translational correlates, and rational therapeutic strategies for overcoming resistance.

Bo Yuan, Wenzhi Deng, Juan Luo et al. · Frontiers in Immunology · 0 citations