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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Wendy Rosenthal

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2 papers indexed here

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Open access Aug 2026

Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy

Tregs engineered with an orthogonal IL-2 tethered to its receptor persisted without exogenous IL-2 and exhibited superior therapeutic efficacy in a mouse model of type 1 diabetes.

Alyssa C. Indart, Huiyun Lyu, V. Nguyen et al. · 0 citations
Open access Sep 2026

Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate

Regulatory T (Treg) cells in mice can lose lineage identity and acquire proinflammatory functions, but whether human Treg cells are similarly susceptible to cytokine-driven destabilization remains unclear. Here we established an in vitro model of human Treg cell destabilization defined by silencing of the lineage-speci...

Patrick Ho, Alexander Vu, Joey C. Leung et al. · 1 citation

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