Author

Wenfeng Yu

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Open access Sep 2026

MAPK3 as a ferroptosis driver in excitatory neurons in Alzheimer’s disease: from genetic causal inference to in vivo functional validation

Introduction Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and ferroptosis-an iron-dependent form of regulated cell death-has been increasingly implicated in AD-related neuronal loss. However, the causal relationship between specific ferroptosis-related genes and AD, particularly within defined...

Xiao-Qiong An, Chang-Ge Wei, Man-Ni Cao et al. · Frontiers in Aging Neuroscie... · 0 citations

Jul 2026

Seipin modulates Alzheimer’s disease pathogenesis by regulating ferroptosis through a glycine-mediated metabolic pathway

Seipin is identified as a novel regulator of ferroptosis in the pathogenesis of AD and the potential of the BSCL2-glycine-ferroptosis axis as a therapeutic target is underscored.

Xiaoqiong An, Daoju Wu, Yijia Wang et al. · Metabolic brain disease · 0 citations