Author

Wenguang Fu

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Open access Aug 2026

A ternary nanocomplex for hepatocyte-targeted gene delivery and treatment of metabolic dysfunction-associated steatotic liver disease

The liver, with its unique physiology and powerful metabolic activity, represents an ideal ‘protein factory’ for gene therapy. Yet efficient, cell-specific transfection of hepatocytes remains a significant challenge. To address this, we engineered a novel ternary nanocomplex through a modular design. A stable binary co...

Xiao-Wei Liu, Meilin Wang, Jiahao Liao et al. · RSC Advances · 0 citations

Review Open access Aug 2026

Non-histone protein L-lactylation in cancer: a metabolic switch for immune evasion and therapeutic resistance

This work defines the spatially compartmentalized catalytic network governing this process, detailing how nuclear EP300/CBP, cytosolic AARS1, and mitochondrial AARS2 mediate stereospecific targeted modifications.

Ying-Ying Guo, Lanyang Gao, Shundan Li et al. · Molecular Cancer · 0 citations

Jul 2026

SERPING1 facilitates colorectal liver metastasis by modulating epithelial-mesenchymal transition and tumor microenvironment remodeling.

BACKGROUND Colorectal liver metastasis (CRLM) remains the primary cause of mortality in patients with colorectal cancer (CRC). Despite its clinical significance, the complex molecular networks and microenvironmental dynamics driving CRLM remain incompletely understood. Identifying robust prognostic biomarkers and eluci...

Wenhao Yu, Boyuan Gu, Zhiwei Huang et al. · Biochimica et Biophysica Act... · 0 citations