α-Lipoic acid (LA) is a naturally occurring small molecule possessing both endogenous cofactor activity and dynamic covalent polymerization capability. The 1,2-dithiolane ring in its structure enables both redox-responsive biological functions and ring-opening polymerization to yield polylipoic acid (PolyLA) with a dyn...
Chun-Yan Cui, Chen-Xi Zheng, Zhen Liu et al.· Chemical Society Reviews· 0 citations
Osteoporosis, featured by imbalanced bone remodeling, faces clinical challenges including microenvironment dysregulation, insufficient mineralization, and poor material fixation. Inspired by natural bone regeneration-where ossification centers and surrounding soft tissues orchestrate mineralization and tissue integrati...
This discussion aims to inspire a reorientation of nanomedicine strategies toward precision therapy for epilepsy by highlighting how emerging nanomedicines are expanding the therapeutic target repertoire to include key non-neuronal nodes, with a focus on neuroinflammation and BBB repair.
Yage Sun, Wenguang Liu· Journal of Controlled Releas...· 0 citations
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