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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Wenjie Huang

h-index 30 View on Semantic Scholar

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Review Aug 2026

Lipid metabolism remodeling the immunological landscape of hepatocellular carcinoma: From mechanisms to therapeutics.

The framework of etiology-driven metabolic-immune interactions is proposed by comparing two major etiologies, HBV and MASLD, taking into account the crucial role of lipid metabolism in hepatocarcinogenesis, dietary interventions and lipid metabolism-targeted therapies have also been included so as to offer potential th...

Kai-Tong Mai, Jun-Qing Jiang, Xiang-Long Ma et al. · 0 citations
Review Open access Sep 2026

Revisiting the immunosuppressive microenvironment in hepatocellular carcinoma: a functional taxonomy of immune cells and therapeutic targeting.

This review provides an integrated and conceptual analysis of the HCC immune landscape, delineating the mechanistic drivers underlying immune suppression, summarizes current immune-based classification frameworks, and dissects the context-dependent functions of key immune cell populations in tumor progression.

Jia-Qian Zhang, Si-Wen Li, Xiang-Long Ma et al. · 0 citations
Open access Jul 2026

Hypoxia tumor-associated macrophages facilitate hepatocellular carcinoma metastasis via uPA-uPAR pathway.

Hypoxia drives TAM heterogeneity in HCC via an H‑TAM‑intrinsic HIF‑1α-uPA axis that engages uPAR on HCC cells to promote metastasis, and dasatinib is a promising therapy to block this axis and improve outcomes.

Yi-Jun Wang, Xiaomin You, Xiangyuan Luo et al. · 0 citations

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