Open access
Jul 2026
β-hydroxybutyrate restores social deficits by suppressing HDAC9 in the ACC of Shank3B-deficient mice.
It is found that KD ameliorates social deficits and induces systemic ketosis with marked elevation of β-hydroxybutyrate (BHB) in KO mice, and HDAC9 is identified as a potential therapeutic target for ASD-related social deficits.
Erling Hu, Jialong Li, Chuchu Qi et al.
· EMBO Molecular Medicine · 0 citations