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Open access Jul 2026

A Platform-Independent Binary Gene-Pair Signature Derived from CRPC-Enriched Single-Cell Transcriptomics for Predicting Recurrence-Free Survival in Prostate Cancer

The 36-gene-pair binary signature provides robust RFS risk stratification, and high-risk individuals exhibit transcriptional similarity to reported anti-PD-1 therapy responders, and CKS2 emerges as a prognostic hub warranting validation.

Yu He, Boyang Li, Zhaojie Tan et al. · 0 citations