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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

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Wifaq M. Ali

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Review Open access Sep 2026

Hypoxia and Epigenetic Reprogramming in Cancer: A Narrative Review of Mechanisms and Therapeutic Implications

Hypoxia stabilizes HIF-1a and HIF-2α, which cooperate with multiple epigenetic regulators, including DNA methyltransferases, histone-modifying enzymes, chromatin remodelling complexes, and non–coding RNAs, which promote EMT, CSC maintenance, immune escape, metastasis, and resistance to chemotherapy and immunotherapy.

Yasamin Al-Qassab, Tharwa H. Al-Tai, Suha A. al-Fakhar et al. · 0 citations

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