Combined disulfiram and MK-8776 treatment reveals cell line–dependent antitumor activity in different 3D ovarian cancer subtypes
Disulfiram (DSF) is an FDA-approved drug with pleiotropic anticancer activity, including induction of cellular stress and effects on stemness-associated phenotypes in ovarian cancer. Here, we investigated whether DSF enhances the antitumor efficacy of the CHK1 inhibitor MK-8776 in ovarian cancer models, with emphasis...