The neonatal heart experiences rapid metabolic growth after birth to meet increasing energetic and biosynthetic demands. How mitochondrial cofactor availability limits this transition remains unclear. Here, we demonstrate that mitochondrial S-adenosylmethionine (mitoSAM) import through SLC25A26 becomes limiting shortly...
Anastasia Rumyantseva, Trevor S. Tippetts, Alissa Wilhalm et al.· Science Advances· 1 citation
Polyadenylation is a conserved post-transcriptional RNA modification with fundamentally different consequences for RNA fate across biological systems. In bacteria, chloroplasts, and plant mitochondria, adenylation is generally associated with RNA turnover and degradation, whereas its role in metazoan mitochondria remai...
Linden S Muellner-Wong, William Carter, C. Freyer et al.· Biochimica et biophysica act...· 1 citation
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