Electrochemiluminescence immunoassay for quantifying ZMA001 in human serum: method development, validation, and clinical pharmacokinetic application.
ZMA001 is a novel human IgG1 monoclonal antibody (mAb) specifically designed to target the N-terminal region of transmembrane lysyl-tRNA synthetase 1 (KARS1), an enzyme implicated in the pathobiology of pulmonary arterial hypertension. The study aimed to develop a bioanalytical method to quantify ZMA001 in human sera t...