William I. Weis

Mechanical opening of the αE-catenin M-region gates afadin condensation in cardiomyocytes

In mechanically active tissues, cell-cell adhesions must withstand high and dynamic loads to maintain tissue integrity. The ability to detect and withstand load centers on the mechanosensitive adherens junction (AJ), which couples the actin networks of adjacent cells. The mechanosensor αE-catenin responds to force by o...