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Author

William J. Liu

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Open access Aug 2026

A structural and mechanistic atlas of NTD antibody neutralization and immune escape across SARS-CoV-2 prototype and its (sub-)variants.

Mechanistic studies reveal that NTD-5 and NTD-9 antibodies neutralize by inducing S1 shedding, thereby extending this mechanism to selected NTD-directed antibodies and providing a structural and mechanistic framework for rational vaccine and antibody design resilient to antigenic drift.

Jian-Jie Zhou, Wen-Yu Li, Xiaoyu Wang et al. · 0 citations
Open access Jul 2026

Mucosal boosting of chimpanzee adenovirus-vectored vaccine encoding SARS-CoV-2 RBD-heterodimer provides robust protection in mice

A chimpanzee adenovirus (AdC68)-vectored vaccine expressing the Delta-XBB receptor-binding domain (RBD)-dimer is constructed and comprehensively compared the immune responses induced by intramuscular injection, intranasal administration, or aerosol inhalation, revealing that aerosol inhalation provided significantly be...

Xue-Yuan Liu, Yaling An, Huixin Duan et al. · 0 citations

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