Open access
Oct 2026
Genomic alterations and treatment define spatiotemporal patterns of glioblastoma recurrence.
The surgical margin is the primary site of glioblastoma recurrence, yet its molecular features remain poorly characterized. We performed histology-guided sampling and single-cell spatial transcriptomics of surgical margin and adjacent recurrent tumor regions, with matched primary tumors from 40 patients. The surgical m...
S. Artzi, D. Harwood, A. Locallo et al.
· Cancer Discovery · 0 citations