Author

William P. Lafuse

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Open access Oct 2026

Lung environment in healthy old age shapes the phenotype and CCR2-mediated recruitment of a subset of apoptotic, high-turnover alveolar macrophages

Immune system changes with healthy aging lead to chronic systemic inflammation termed inflammaging, contributing to age-related pathologies. Alveolar macrophages (AMs) maintain lung homeostasis and health. The impact of inflammaging on AM populations requires further definition. Herein, we examined the effect of he...

S. Pahari, Miranda Lumbreras, A. Paul et al. · Nature Communications · 0 citations

Review Open access Jul 2026

Chronic Social Stress and Immune Dysregulation: Integrating Neuroendocrine Signaling, Microbiota, and Tissue-Specific Responses

Using social defeat and social isolation in mice as model systems, it is highlighted how chronic social stress reprograms immune responses in key tissues, including the lung, brain, and gut.

William P. Lafuse, Murugesan V. S. Rajaram · Cells · 0 citations