Epigenetic Repression of TP53 Transcription Underlies Cancer Cell Persistence for Carboplatin Resistance in Non-Small Cell Lung Cancer
Results demonstrate for the first time that TP53 expression is dynamically regulated at the transcriptional level through promoter methylation related to the drug tolerance, emphasizing that epigenetic silencing, rather than exclusive genetic loss-of-function, contribute to platinum resistance and underscore the therap...