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Author

Wu-Han Xiao

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3 papers indexed here

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Open access Sep 2026

MAVS undergoes aggregation under hypoxia to enhance the hypoxia signaling pathway by promoting the generation of mitochondrial ROS.

The mitochondrial antiviral signaling protein (MAVS) is a key component of the innate immune response against RNA viruses. Its involvement in other cellular stresses is largely unknown. Here, we found that hypoxia induces MAVS aggregation, leading to the stabilization of HIF1/2α proteins and the enhancement of hypoxia...

Xueyi Sun, Chunchun Zhu, Wen Liu et al. · 0 citations
Aug 2026

The loss of aars1 in zebrafish increases tolerance to hypoxia by reducing hif1α degradation via the autophagy-lysosome pathway.

Alanyl-tRNA synthetase 1 (AARS1) has been identified as an enzyme that can recognise L-lactate directly and function as a lactyltransferase. However, its potential regulatory role in hypoxia tolerance remains unclear. In this study, we generated aars1 mutants in zebrafish using the CRISPR/Cas9 technique. We found that...

Ya-Nan Song, Zhi Li, Le Yuan et al. · 0 citations
Open access Aug 2026

SET7-mediated methylation of IRF3 at lysine 98 attenuates antiviral innate immunity.

SET7 belongs to the SET domain (SETD) methyltransferase family, which catalyzes the monomethylation of lysine residues in histones and nonhistone proteins. This process can either enhance or suppress gene activation. Interferon regulatory factor 3 (IRF3) is a key transcription factor in the type I interferon (IFN) sign...

Hong-Yan Deng, Xueyi Sun, Huangyuan Zha et al. · 0 citations

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