Wu-Tao Chen

Single-cell lineage tracing in tumor organoids identifies expansion states depicting the origin and progression of lung adenocarcinoma

Introduction Only a subset of epithelial cells can initiate progressive lung adenocarcinoma (LUAD), yet the founder cell states that confer this competence remain poorly defined. Methods We established a barcoded KrasG12D, Trp53 loss mouse LUAD organoid model that couples 15-nucleotide lineage tracing with single-cell...