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Conditional diffusion for single-cell Hi-C data imputation and enhancement with scHiC-Diff

Single-cell high-throughput chromosome conformation capture (scHi-C) enables the analysis of cell-to-cell variability in three-dimensional (3D) genome organization, but its utility is severely limited by pervasive technical dropouts, leading to extremely sparse contact maps. Accurately identifying dropout events and im...

Wuhao Liu, Zhaoyu Fang, Xuyan Du et al. · 0 citations

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