Focused Ultrasound-Enhanced Drug Delivery to Brain Tumors: Quantitative and Translational Insights from CNS Physiologically Based Pharmacokinetic Modeling.
PURPOSE Successful clinical translation of focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening strategy to brain cancer therapy has been hindered by limited quantitative understanding of CNS pharmacokinetics. Using a physiologically based pharmacokinetic (PBPK) modeling framework, this study aimed to qua...