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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

X. Chang

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Open access Aug 2026

Shared genetic architecture and therapeutic targets across paediatric immune-mediated diseases.

OBJECTIVES Paediatric-onset immune-mediated inflammatory diseases (IMIDs), including juvenile idiopathic arthritis and related rheumatic diseases, remain genetically undercharacterised. We aimed to define shared and category-specific genetic architecture across paediatric IMIDs, compare signals with adult IMIDs, and id...

Jin Li, Hui-Qi Qu, Michael E. March et al. · 0 citations
Open access Jul 2026

Drug repurposing opportunities across 92 CNS-related conditions using deep learning and whole-genome sequencing

CNS-related conditions span tumors, vascular, neurodevelopmental, and psychiatric disorders, yet therapeutic development for CNS disorders continues to face persistent delays and high attrition due to blood–brain barrier constraints, biological heterogeneity, and limited predictive models. Drug repurposing can shorten...

Yi-Chuan Liu, Hui-Qi Qu, F. Mentch et al. · 0 citations

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