Cytochrome P450 dimerases generate the remarkable structural diversity of dimeric diketopiperazine (DKP) natural products through highly selective intermolecular radical-mediated reactions. Although radical addition mechanisms have been established for most bacterial DKP dimerization modes, the molecular basis underl...
Ye-Qing Du, Tai-Ping Zhou, Wen-Ya Tian et al.· Journal of the American Chem...· 0 citations
Biocatalytic regioselective acylation is a powerful strategy for diversifying natural products and optimizing their pharmacological properties. Compared with plant acyltransferases (ATs), bacterial tailoring ATs remain poorly understood. AntB from the antimycin pathway was previously reported to possess acyl-donor prom...
Meng-Meng Zheng, Yu-Han Dai, Xiang-Yu Li et al.· Angewandte Chemie· 0 citations
3’-Sialyllactose (3’-SL), the simplest sialylated human milk oligosaccharide (HMO), is widely incorporated into infant formula due to its roles in shaping the gut microbiota, inhibiting pathogen adhesion, and supporting neurodevelopment. In this study, we developed an efficient microbial cell factory for 3’-SL producti...
Yan Wu, Tao-Ling Min, Zhenfeng Ma et al.· Bioresources and Bioprocessi...· 0 citations
PbrC16, a FabV-family ER from a manumycin-type biosynthetic gene cluster (BGC) in Peterkaempfera bronchialis is characterized and reveals the molecular basis for its exceptional substrate promiscuity and versatile acyl carrier protein (ACP) recognition.
Yan Gao, Kai Jiang, Yu-Han Dai et al.· Journal of the American Chem...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
