Oct 2026
Clinical utility of plasma APOE proteotyping for Alzheimer's disease risk and prognosis
R. Shi, L. Choity, M. Farinas et al.
· medRxiv · 0 citations
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Open access
Oct 2026
Analytical performance of a delayed-centrifugation blood collection tube for remote blood biomarker assessment
Current biobanking guidelines require in-person blood collection and immediate processing for Alzheimer's disease (AD) biomarker assessment. We recently reported that the P100 blood collection tubes containing protease inhibitors improve protein biomarker stability over delayed centrifugation periods. However, whether...
Yron K. Lee, X. Zeng, M. Farinas et al.
· medRxiv · 0 citations
Open access
Oct 2026
Brain region- and solubility-dependent proteomic signatures of neurofibrillary tangle pathology in Alzheimer's disease
Neurofibrillary tangles (NFTs) are a hallmark of Alzheimer's disease. However, the molecular basis underlying their spatial heterogeneity and biochemical complexity remain unclear. To address this, we performed mass spectrometry-based proteomic profiling of two neocortical regions with different susceptibilities to NFT...
X. Zeng, E. Abrahamson, W. G. Balogun et al.
· medRxiv · 0 citations