Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia
ABSTRACT Primary immune thrombocytopenia (ITP) is an autoimmune disease, in which B‐lymphocytes drive autoantibody production and maintain pro‐inflammatory microenvironments. Single‐cell RNA sequencing (scRNA‐seq) datasets were conducted on peripheral blood mononuclear cells samples (4 ITP and 4 thrombocytosis patients...