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Author

Xi-Jing Chen

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Sep 2026

A Platinum(IV)-Ursolic Acid Conjugate Overcomes Cisplatin Resistance in Ovarian Cancer by Targeting XPO1 and PARP1

Cisplatin is a cornerstone chemotherapeutic for ovarian cancer, yet its clinical utility is constrained by severe systemic toxicity and acquired drug resistance. Here we report a novel platinum (IV) prodrug, US-CIS-OH, generated by conjugating cisplatin with ursolic acid (UA), a natural pentacyclic triterpenoid with...

Zi-Qi Pan, Zhi-Ying Qin, Zi-Yu Qian et al. · 0 citations
Oct 2026

Discovery of LB10, a Potent and Orally Bioavailable Inhibitor of Ecto-5′-Nucleotidase as a Single Agent or in Combination for the Treatment of Lung Cancer

Ecto-5-nucleotidase (CD73), a rate-limiting enzyme in the adenosine pathway, plays a crucial role in mediating tumor immunosuppression and has emerged as an attractive target for cancer immunotherapy. A series of aryl alkyl ether-based CD73 inhibitors were designed and synthesized. Compound LB10 stood out as the most...

Yu Xu, Wan Zhang, Zhi-Ning Liu et al. · 0 citations

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