Dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway of phytopathogenic fungi, has emerged as a promising target for fungicide discovery. In this study, compound VS-24 was identified from a commercial chemical library using molecular docking-based virtual screening and bioac...
Guo-Tai Lin, Jia-Qi Wu, Jia-Yi Zhu et al.· Journal of Agricultural and...· 0 citations
Natural products (NPs) serve as both inspirations and resources for the discovery of bioactive compounds. However, their application in green agrochemical discovery faces limitations such as low activity, short duration of efficacy, potential toxicity and residue issues from structural modifications, and constraints in...
Peng Lei, H. Yuan, Xingxing Lu et al.· Science Advances· 0 citations
BACKGROUND
Soybean root rot (SRR) is a devastating disease that severely reduces yield and quality in China, with Fusarium oxysporum recognized as one of the most prevalent causal agents. Pydiflumetofen, a new-generation succinate dehydrogenase inhibitor (SDHI) fungicide, exhibits potent efficacy against Fusarium spp....
Yuan-Yuan Cai, Yu Liu, Zhao-Ru Li et al.· Pest Management Science· 0 citations
Durian cultivation has become a key development industry in China in recent years, and durian root rot (DRR) constitutes a major threat to production. In this study, symptomatic root and stem base tissues and leaves were systematically collected from the main durian-producing regions of China, yielding 202 fungal and o...
Yun Xing, Hou-Ya Fang, Yi-Jia Deng et al.· Microorganisms· 0 citations
It is demonstrated that PsORP1 of Phytophthora sojae specifically localises to ER–Golgi membrane contact sites (MCSs) and is indispensable for vegetative growth and asexual/sexual development of P. sojae and elucidates that oxathiapiprolin directly targets the ORD to competitively block this lipid exchange, providing a...
Phytophthora sojae poses a major threat to global soybean production. Here, CRISPR/Cas9-mediated promoter replacement revealed that the V-ATPase A subunit gene (PsVHA-A) plays an important role in the growth, development, and pathogenicity of P. sojae, highlighting its potential as a molecular target. Using this target...
Xingxing Lu, Xixi Wang, Xinxin Li et al.· Journal of Agricultural and...· 0 citations
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