Non-canonical modulation of mitochondrial ROS and dynamics by Netrin-3 drives inflammasome activation in cardiomyocytes.
BACKGROUND Heart failure is driven by pathological remodeling in which inflammation and mitochondrial dysfunction reinforce each other, yet the molecules that coordinate this interplay remain poorly defined. Netrin-3 is a guidance cue with no known function in the heart. We asked whether Netrin-3 acts in cardiomyocytes...