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Xi-Yan Wang

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Review Open access Sep 2026

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

ABSTRACT Lysosome‐targeting chimeras (LYTACs) have emerged as a strategy for eliminating secreted, extracellular, and plasma‐membrane proteins by redirecting them to the endolysosomal system. By coupling target recognition to receptor‐mediated uptake, LYTACs exploit endogenous trafficking pathways to access disease‐ass...

Ke Liu, Xi-Yan Wang, Xiao-Zhen Liu et al. · 0 citations

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