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Xi-Yuan Wang

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Open access Oct 2026

Enhanced Synaptic-Related Transcriptional Programs in Human Forebrain Organoids for Modeling Synaptopathy-Associated Neurodevelopmental Disorders

Human cerebral organoids (COs) are well-recognized in vitro models for recapitulating human fetal brain development. However, spontaneous unguided differentiation of COs leads to severe regional heterogeneity, limiting standardized research and high-throughput drug screening. In this study, we generated optimized human...

Xiu-Ping Zhang, Ling-Liang Zhang, Xi-Yuan Wang et al. · 0 citations

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