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Author

Xiakun Chu

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3 papers indexed here

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Open access Sep 2026

Membranes Decouple α-Synuclein Surface Assembly and Kinetic Restriction from Persistent Amyloid-like Intermolecular Organization

Membrane association places α-synuclein (αSyn) at the boundary between physiological surface organization and pathological amyloid assembly, supporting vesicle clustering, surface condensation, and amyloid nucleation. How interfacial recruitment, condensate cohesion, and persistent amyloid-like organization are coupl...

Jin-Yu Chen, Xia-Kun Chu · 0 citations
Open access Sep 2026

Single-Chain Conformational Fluctuation Regulates Phase Separation of Intrinsically Disordered Proteins

Intrinsically disordered proteins (IDPs) form biomolecular condensates through weak multivalent interactions, but the ensemble variables that control condensate stability and material properties remain incompletely defined. Most current descriptions emphasize sequence features or mean single-chain descriptors, such a...

Ci-Bo Feng, Shiqinrui Xu, Hai-Bin Su et al. · 0 citations
Open access Aug 2026

Phosphorylation and pocket-binding ligands rewire the coupled networks in multidomain protein condensate

Biomolecular condensates formed by multidomain proteins are increasingly linked to disease and are emerging targets for chemical modulation. Yet most molecular models emphasize intrinsically disordered regions (IDRs), whereas many available ligands bind folded-domain pockets. How IDR modifications and folded-domain lig...

Yu Cao, Jin-Yu Chen, Xia-Kun Chu · 0 citations

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