Overall, DAMP-directed intervention in skeletal muscle will likely require selective and context-dependent modulation that limits pathological inflammation while preserving physiological repair and regeneration.
Zi-Hui Gao, Xia Li, Ya-Nan Ji et al.· Biochemical Pharmacology· 0 citations
How neuroendocrine alterations drive downstream molecular mechanisms-specifically neuroinflammation, a shift in the kynurenine pathway, mitochondrial dysfunction, and impaired brain-derived neurotrophic factor (BDNF) signaling-that collectively remodel stress-related brain circuits are explored.
Xia Li, Yanbei Zhu, Ya-Nan Ji et al.· Biochemical Pharmacology· 2 citations
This review systematically elucidates the molecular activation mechanisms of the cGAS–STING pathway and its complex regulatory networks within tumors, with a particular focus on analyzing its dual functions—tumor immune surveillance versus tumor promotion—and the determining factors involved.
Haiyan Jiang, Zhanzhan Li, Xia Li et al.· Frontiers in Pharmacology· 2 citations
This review systematically elaborates on the key pathological roles and molecular mechanisms of ERS and the triggered UPR in Parkinson's disease and discusses various intervention approaches, their research progress, and associated challenges.
Xin Chen, Zihao Zhao, Xinlei Yao et al.· Biochemical Pharmacology· 6 citations
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