Cellular senescence plays a critical role in physiological and pathological processes. This study aims to elucidate the contribution of cellular senescence-related genes to disease etiology. We investigated a cohort study of 439,501 individuals, which included 22 cancers and 9 non-cancer diseases. We found that HLA-E a...
Bin Liu, Wei-Dong Wu, Chang Liu et al.· Molecular Carcinogenesis· 0 citations
Current evidence on the roles of the immune microenvironment and individual heterogeneity in shaping the pathogenesis and treatment landscape of Myasthenia gravis is discussed, emphasizing the transition from phenotype-based disease classification toward immune endotype-driven precision medicine within population heter...
Xia Xue, Chang Liu, Chunjing Qiu et al.· Frontiers in Immunology· 0 citations
This review summarizes current understanding of the cellular and molecular drivers of fibrotic tumor stroma, highlighting heterogeneous cancer-associated fibroblast (CAF) types, and provides a comprehensive framework for understanding how tumor-associated fibrosis regulates cellular immunity across cancers.
