Xian-Dong Meng

Microbiota- and diet-specific T cells become Tregs by default

CD4+ T cells recognize antigens from microbiota, diet, and pathogens via T cell receptors (TCRs) and orchestrate immunity by differentiating into tolerogenic regulatory (Treg) or pro-inflammatory effector (Teff) lineages (e.g. TH1 or TH17) (1). Dysregulation of these responses underlies numerous gastrointestinal inflam...