Author

Xian-Gao Huang

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Open access Oct 2026

Combating CD24 to overcome CD19 CAR-T resistance via induction of innate and adaptive immunity in B-cell malignancies.

This study developed a CD24’sAb and CXCR3-armed CD24 CAR-T cells, both exhibiting potent antitumor activity in lymphoma and leukemia models, and engineered a dual-specific, dual-functional CD19 CAR-T that secretes a CD24 bispecific T-cell engager (CD24 BiTE), enabling simultaneous targeting of CD19 and CD24 to address...

Qing Yin, Jing Gao, Xian-Gao Huang et al. · Leukemia · 0 citations

Open access Sep 2026

PAXIP1-PAGR1 directs cohesin recruitment during break-induced telomere repair

Cohesin is a conserved multiprotein complex (SMC1, SMC3, RAD21, and either STAG1 or STAG2) that organizes three-dimensional genome architecture and regulates chromosome segregation, gene expression, and DNA damage repair1–4. Following double-strand breaks (DSBs), cohesin is recruited to sites of DNA damage - a process...

S. Hwang, Xiao-Ying Wu, Xian-Gao Huang et al. · bioRxiv · 0 citations