Sep 2026
An Enzyme from a Single P450 Monooxygenase Clade Orchestrates Six‑Electron Oxidation for Cyclopeptide Modification
The oxidative modification of complex natural products is critical for their biological activity. However, the enzymatic mechanisms that facilitate three-step, six-electron transfer reactions, such as the conversion of a methyl group to a carboxylic acid, on cyclopeptide scaffolds remain poorly understood. This study...
Ming Peng, Qiao-Ling Wu, Ying-Ying Chen et al.
· ACS Catalysis · 0 citations