Harnessing Regiodivergence and Enantioselectivity in Hydroamidation of Methylenecyclopropanes by Ligand Control.
Hydroamination/hydroamidation has been recognized as a highly important reaction for delivering complex amines. Hydroamination of aliphatic olefins may occur with ipso- and remote selectivity. Yet, controlling or even reversing the regioisomeric outcomes of the hydroamination of aliphatic olefins constitutes a challeng...