Open access
Sep 2026
HEATR1 deficiency enhanced gastric cancer cell PANoptosis to boost anti-tumor immunity
Despite the promise of immune checkpoint inhibitors (ICIs) for gastric cancer (GC) treatment, limited cytotoxic T cell infiltration remains a major barrier to therapeutic efficacy. This study investigates whether targeting HEAT repeat containing 1 (HEATR1) can induce immunogenic PANoptosis to enhance anti-tumor immunit...
Ya Huang, Qing Xu, Mei Zhu et al.
· Molecular Medicine · 0 citations