Open access
Sep 2026
VirPLM: Antigenic prediction of influenza A/H3N2 viruses with a fine-tuned protein language model.
MOTIVATION Human influenza A/H3N2 viruses undergo rapid antigenic evolution primarily driven by the hemagglutinin subunit 1 (HA1). Within HA1, amino acid substitutions under immune pressure cause antigenic drift, necessitating frequent updates to vaccine strains. While hemagglutination inhibition (HI) assays remain the...
Xing-Yi Li, Ke-Xin Xiao, Chun-Yan Zhou et al.
· Bioinformatics · 0 citations